Suspensión de talco para efusión pleural maligna

MARÍN POZO, J F; MORENO VILLAR, Mª A; SORIANO MARTINEZ, Mª; RODRÍGUEZ TORNÉ, G; VÍLCHEZ MEDINA, T; MILLÁN GARCÍA, R; RUIZ DÍAZ, Mª J

Farmacia Hospitalaria

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El talco es uno de los agentes esclerosantes más efectivos de los que se dispone actualmente para el tratamiento de la efusión pleural maligna. Al no existir como preparado comercial es necesario proceder a su formulación, siendo el aspecto más problemático la esterilización. En el presente trabajo se describe la preparación de una suspensión de talco, usando como método de esterilización el calor húmedo. La fórmula que se propone es segura, de fácil elaboración, efectiva y de bajo coste. Asimismo se valora la efectividad de dicha fórmula en un total de 10 pacientes, obteniendo un porcentaje de efectividad del 80%. La incidencia de efectos adversos fue baja y concordante con los datos publicados en la literatura.

Palabras clave:

Efusión pleural maligna

Pleurodesis

Talco

Esterilización

Talc is one of the most effective sclerosing agents currently available for the treatment of malignant pleural effusion. As no proprietary preparations is readily available, it must be formulated, its most difficult aspect being sterilisation. In this work the preparation of a talc suspension using wet heat as sterilising method is described. The recommended formula is safe, easy to manufacture, effective, and low-cost. Moreover, this formula¿s effectiveness is assessed in 10 patients, the effectiveness percentage obtained being 80%. The incidence of adverse effects was low and matched data reported in the literature.

Keywords:

Malignant pleural effusion

Pleurodesis

Talc

Sterilisation

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