Información de la revista
Vol. 38. Núm. 6.
Páginas 486-487 (noviembre - diciembre 2014)
Visitas
1092
Vol. 38. Núm. 6.
Páginas 486-487 (noviembre - diciembre 2014)
CARTAS AL DIRECTOR
Acceso a texto completo
Resistant hypertension in pediatric end stage renal disease
Hipertensión resistente en enfermedad renal terminal pediátrica
Visitas
1092
Virginia Martínez-Santana1, Silvia Marique-Rodríguez2, Ana Belén Martínez2, Olalla Álvarez2
1 Fundació Hospital de l’Esperit Sant. Barcelona.
2 Hospital General Universitario Gregorio Marañón. Madrid. España.
Este artículo ha recibido
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (1)
Texto completo
Introduction

Chronic kidney disease (CKD) is defined as the irreversible loss of kidney function, producing progressive decrease in glomerular filtration up to achieve the so-called end stage renal disease (ESRD)1.

The long-term survival in children with ESRD has improved but mortality is still about 30 times higher than expected for age. This increases the need for extreme vigilance to achieve the best therapeutic results with less risk2.

According to The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines, CKD is classified into five stages of increasing severity3. The renal disease progression to ESRD is largely due to secondary factors that may vary, such as hypertension and proteinuria, whose control is vital because it can prevent the progression of kidney damage.

The tight control of blood pressure (BP) is crucial. Initially antihypertensive therapy was performed empirically. Subsequent data in adults suggest superiority of angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) as compared to other antihypertensive agents (diuretics, calcium channel blockers, β-blockers) resulting in a change of pharmacotherapeutic strategy4.

Following the results of the ESCAPE trial5, which established the need of strict control of BP, the European Society of Hypertension6 set new standards in treating hypertension in children with CKD: target of BP of the 75th percentile in patients without proteinuria and of the 50th percentile in children with proteinuria. It is called resistant hypertension when BP is above the target value despite treatment with three antihypertensive drugs4.

Proteinuria is not only a marker of kidney disease but also a risk factor for progression of CKD. Data from the European Study Group of Nutritional Treatment of Chronic Renal Failure in Childhood show that urinary protein excretion greater than 60mg/m2/h represents a high risk of progression of CKD7.

Drugs that block the renin-angiotensin-aldosterone system have shown to reduce proteinuria. Consequently, it has been suggested that even normotensive patients should be treated with ACE inhibitors or ARBs if proteinuria is present8.

Case Report

Preterm infant admitted for prematurity, peculiar phenotype and suspected fetal distress. After 48 hours of life he became edematous with hyponatremia and albumin of 1.2 g/dl. Renal function was evaluated, with GFR 45 ml/min/73m2, proteinuria 92 mg/m2/h, creatinine 0.5 mg/dl and urea 22 mg/dl, fulfilling diagnostic criteria for nephrotic syndrome.

The patient required fluid restriction, and transfusions of albumin 0.8 g/kg/day with furosemide 0.5 mg/kg, with which he gradually improved. Captopril 0.2 mg/kg every 8 hours was also initiated. It was well tolerated but with little improvement in proteinuria (47 mg/m2/h).

The patient showed persisting high proteinuria, and was stable from a clinical perspective with a tendency to slight palpebral edema without ascites. His diuresis was 2 ml/kg/h. At 6 weeks of age, the patient was discharged from the hospital.

At 2 months of age, the patient required hospital admission from the emergency department due to edema, fever and irritability. Gammaglobulin and infusions of albumin and furosemide were administered. This was well tolerated by the patient, with a decrease in edema. At 7 months of age the patient began to have higher BP values (100/60 mmHg), so spironolactone 3mg every 24 hours was added to captopril. Increased values of creatinine 25.0 mg/dl, and protein 757 mg/dl were identified in urine.

At 9 months of age, the patient had a g-tube placed and remained under permanent clinical follow-up. The progression of the disease led to automated peritoneal dialysis (APD) at 16 months of age. Indomethacin was also initiated, reaching 2.5 mg/kg/day with increased blood albumin and improved ultrafiltration. BP values occasionally improved: 77/48 mmHg.

Despite APD and captopril, the patient continued with proteinuria and hypertension. This was later on replaced by enalapril 0.4 mg/kg/day plus nicardipine 1.5 mg/kg/day, labetalol 8.3 mg/kg/day and nifedipine on demand. Losartan was added to treatment, with limited therapeutic success. Figure 1 shows the evolution of proteinuria (mg/dl) from birth to the onset of automated peritoneal dialysis.

Figure 1.

Evolution of proteinuria (mg/dl) from birth to the onset of automated peritoneal dialysis.

(0.04MB).

Finally, at 30 months of age, the patient underwent bilateral nephrectomy due to uncontrolled hypertension, thereby stabilizing the BP.

Discussion

The pharmacotherapeutic approach to the clinical management of this case was based on the recommendations made by the pediatric working groups5,6. Just as in adults, some of the antihypertensive drugs that may be administered in children are ACE inhibitors, ARBs, calcium antagonists, beta-blockers and diuretics.

Antihypertensive agents used were ACE inhibitors and ARBs, as discussed above, not only for having shown to reduce BP and proteinuria, but also for having a higher level of evidence. There is little information in literature that supports the use of other antihypertensive drugs in children and adolescents once ACE inhibitors or ARBs have failed4.

The logical sequence of pharmacotherapeutic management in pediatric patients with CKD/ESRD has not been described. Sometimes the situation is severe and to achive an adequate hypertension control inevitably leads to nephrectomy. This case may serve to raise the need to establish a treatment schedule in those cases where ACEIs or ARBs have not been effective.

The optimal management of children and adolescents with CKD/ESRD requires the development of a therapeutic scheme with sufficient scientific evidence to ensure maximum efficiency and safety.

Bibliography
[1]
Warady BA , Chadha V .
Chronic kidney disease in children: the global perspective.
Pediatr Nephrol., 22 (2007), pp. 1999-2009
[2]
Fernández-Llamazares CM , Manrique-Rodríguez S , Sanjurjo-Sáez M .
Drug use safety in paediatrics.
Arch Argent Pediatr., 109 (2011), pp. 510-518
[3]
National Kidney Foundation.
K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.
Am J Kidney Dis., 39 (2002), pp. S1-266
[4]
Simonetti GD , Bucher BS , Tschumi S , et al.
Arterial hypertension and proteinuria in pediatric chronic kidney disease.
Minerva Pediatr., 64 (2012), pp. 171-182
[5]
Wühl E , Trivelli A , Picca S , et al.
Strict blood-pressure control and progression of renal failure in children.
N Engl J Med., 361 (2009), pp. 1639-1650
[6]
Lurbe E , Cifkova R , Cruickshank JK , et al.
Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension.
J Hypertens., 27 (2009), pp. 1719-1742
[7]
Wingen AM , Fabian-Bach C , Schaefer F , et al.
Randomised multicentre study of a low-protein diet on the progression of chronic renal failure in children. European Study Group of Nutritional Treatment of Chronic Renal Failure in Childhood.
Lancet., 349 (1997), pp. 1117-1123
[8]
Simonetti GD , Santoro L , Ferrarini A , et al.
Systemic hypertension and proteinuria in childhood chronic renal parenchymal disease: role of antihypertensive drug management.
Paediatr Drugs., 9 (2007), pp. 413-418
Copyright © 2014. Sociedad Española de Farmacia Hospitalaria
Descargar PDF
Idiomas
Farmacia Hospitalaria
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.