Study of drug dose calculation for morbidly obese patients

Serra Soler, G.; Galán Ramos, N.; Martínez-López, I.; Delgado Sánchez, O.; Quevedo Juanals, J.

doi:10.1016/S2173-5085(09)70097-8

Farmacia Hospitalaria

ISSN: 1130-6343

Farmacia Hospitalaria (Farm Hosp) is the official publication of the Spanish Society of Hospital Pharmacists (SEFH), a professional and scientific organization that currently has about 4.351 members.

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We included 62 patients. The mean number of medications prescribed per patient was 12.1 (4–39), and an average of 2.4 (1–10) are listed in the recommendations. A total of 135 drugs were prescribed. Dose calculations for 81 of the above (60%) coincided with recommendations and 54 (40%) did not; there were 51 cases of underdosing and three cases of overdosing.

Discussion

Improper dosing was detected for prescriptions in the systemic antibiotic and antithrombin drug groups, with underdosing being more common than overdosing.

Keywords:

Morbid obesity

Obesity

Drug dosage calculations

Medications

Recommendations

Resumen

Introducción

El objetivo del trabajo es analizar la adecuación de la dosificación de los fármacos en los pacientes hospitalizados con obesidad mórbida y sus características.

Métodos

Estudio retrospectivo y descriptivo de la dosificación de los fármacos prescritos a los pacientes hospitalizados con obesidad mórbida en un hospital de tercer nivel durante el año 2007. Se ha utilizado como estándar las recomendaciones elaboradas por el servicio de farmacia.

Resultados

Se incluyó a 62 pacientes. La media de las especialidades farmacéuticas prescritas por paciente fue 12,1 (4–39), y 2,4 (1–10) la de los fármacos incluidos en las recomendaciones, con un total de 135 especialidades prescritas. La dosificación de 81 (60%) de ellas coincidía con las recomendaciones y 54 (40%) no; en 51 casos fue por infradosificación y en 3, por sobredosificación.

Discusión

Se detecta dosificación inadecuada de los fármacos prescritos de los grupos antibióticos sistémicos y antitrombóticos, con predominio de la infradosificación.

Palabras clave:

Obesidad mórbida

Obesidad

Dosificación de fármacos

Medicamentos

Recomendaciones

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☆

The preliminary results of this study were presented on the 53rd Spanish National Congress of the Spanish Society of Hospital Pharmacy and the 1st Latin American Meeting of Hospital Pharmacists.

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